THE INACTIVATION OF TRYPSIN
نویسندگان
چکیده
منابع مشابه
The Inactivation of Trypsin
1. A study has been made of the equilibrium existing between trypsin and the substances formed in the digestion of proteins which inhibit its action. 2. This substance could not be obtained by the hydrolysis of the proteins by acid or alkali. It is dialyzable. 3. The equilibrium between this substance (inhibitor) and trypsin is found to agree with the equation, trypsin + inhibitor right harpoon...
متن کاملThe Inactivation of Trypsin. I
In most of the early work of the kinetics of enzyme action it was tacitly assumed that enzyme reactions obeyed the law of mass action and that they represented a special case of homogeneous catalysis. As the individual enzymes were studied more carefully, however, itbecame apparent that few, if any, obeyed the law of mass action in its simplest form. Several authors have, therefore, taken the v...
متن کاملInactivation of Crystalline Trypsin
1. The rate of inactivation of crystalline trypsin solutions and the nature of the products formed during the inactivation at various pH at temperatures below 37 degrees C. have been studied. 2. The inactivation may be reversible or irreversible. Reversible inactivation is accompanied by the formation of reversibly denatured protein. This denatured protein exists in equilibrium with the native ...
متن کاملThe Inactivation of Trypsin by X-rays
1. The inactivating effect of soft x-rays on trypsin in solutions of various degrees of concentration has been studied. 2. It has been found to run parallel with spontaneous heat inactivation. It is almost, if not entirely, confined to the free or active trypsin. 3. Under radiation of constant intensity, the inactivation follows the simple exponential law which indicates a monomolecular reactio...
متن کاملMechanism of inactivation of trypsin by antithrombin.
General aspects of the mechanism of antithrombin action were elucidated by a comparison of the inactivation of trypsin by antithrombin with the inactivation of coagulation proteinases by the inhibitor. Bovine antithrombin and bovine trypsin were shown to form an inactive equimolar complex. A non-complexed, proteolytically modified form of antithrombin, electrophoretically identical with that fo...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1922
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.4.3.261